Humanitarian crisis in Yemen remains the worst in the world.

Join us: facebook.com/unitedhumanists

Humanitarian crisis in Yemen remains the worst in the world.

According to the Office for the Coordination of Humanitarian Affairs (OCHA) the “severity of needs is deepening”, with the number of people in acute need, a staggering 27 per cent higher than last year, when it was already the most acute crisis on the globe.

Thursday’s 2019 Humanitarian Needs Overview for Yemen report, shows that 14.3 million people are classified as being in acute need, with around 3.2 million requiring treatment for acute malnutrition; that includes two million children under-five, and more than one million pregnant and lactating women.

Highlighting that more than 20 million people across the country are food insecure, half of them suffering extreme levels of hunger, the report focuses on some key humanitarian issues: basic survival needs, protection of civilians and livelihoods and essential basic services.

“The escalation of the conflict since March 2015 has dramatically aggravated the protection crisis in which millions face risks to their safety and basic rights”, OCHA reports.

The UN agency data shows that a total of 17.8 million people lack access to safe water and sanitation, and 19.7 million lack access to adequate healthcare. Poor sanitation and waterborne diseases, including cholera, left hundreds of thousands of people ill last year.

Meanwhile, grain which could help feed millions, is still at risk of rotting in a key Red Sea storage facility because conditions are too unsafe to reach it, UN Special Envoy Martin Griffiths and UN Emergency relief chief Mark Lowcock said earlier this week.

Death toll and displaced people

During the past four years of intense conflict between Government forces and Houthi rebels have left tens of thousands dead or injured including at least 17,700 civilians as verified by the UN.

The agency adds that an estimated 3.3 million people remain displaced, up from 2.2 million last year, including 685,000 people who fled fighting in Hudaydah and on the west coast, from June onwards. According to the UN Refugee Agency (UNHCR), the number of sites hosting displaced people has increased by almost half over the past 12 months.

Pledging conference

In a bid to respond to the urgent humanitarian needs, the United Nations and the Governments of Sweden and Switzerland will convene the third High-Level Pledging Event for the Humanitarian Crisis in Yemen, later this month.

The event is scheduled for 26 February in Geneva and seeks to garner support for the humanitarian response and alleviate the suffering of the Yemeni people. At the beginning of this month, UN Emergency relief chief Mark Lowcock said that $4 billion would be needed.

Source: http://bit.ly/2jJ7Hi9

Advertisements

A Breakthrough in the Mystery of Why Women Get So Many Autoimmune Diseases.

Join us: facebook.com/unitedhumanists

A Breakthrough in the Mystery of Why Women Get So Many Autoimmune Diseases.

About 65 million years ago, shortly after the time of the dinosaurs, a new critter popped up on the evolutionary scene. This “scampering animal,” as researchers described it, was likely small, ate bugs, and had a furry tail. It looked, according to artistic renderings, like an especially aggressive New York City rat. And it had a placenta, an organ that grows deep into the maternal body in order to nourish the fetus during pregnancy.

The rodentlike thing would become the common ancestor of the world’s placental mammals, with descendants that include whales, bats, dogs, and humans, among many other species. And today, the placenta might hold the key to one of the most enduring mysteries in human medicine: Why do women suffer much higher rates of autoimmune disease than men do?

Autoimmune diseases turn people’s own immune systems against their bodies. In the United States alone, women represent 80 percent of all cases of autoimmune disease. Women are 16 times more likely than men to get Sjogren’s syndrome, in which the immune system goes after the glands that make tears and saliva, and nine times more likely to have Hashimoto’s thyroiditis, in which it sets its sights on the thyroid. Sjogren’s forced Venus Williams to drop out of the U.S. Open in 2011. The singer Selena Gomez underwent a kidney transplant after suffering complications from lupus, which is eight times more common in women than in men.

Some scientists now think the placenta itself might be the reason why women are so disproportionately affected. In a paper published last week in the journal Trends in Genetics, Melissa Wilson, an evolutionary biologist, along with her colleagues from Arizona State University, put forward an explanation called the “pregnancy-compensation hypothesis.” It suggests that women’s immune systems are engaged in a fierce tug of war with placentas, even when the organs aren’t actually present.

Here’s how the theory goes: Women—and all other placental mammals—evolved such that they would be pregnant for many of their adult years. Before the advent of birth control, that was pretty much the fate of the female sex. In modern hunter-gatherer populations, Wilson told me, it’s not uncommon for women to have eight to 12 children each.

Though bearing so many babies might sound grueling, women’s bodies evolved to cope. When the placenta grows during pregnancy, the organ sends signals to the mother’s immune system to change its activity so that the mother’s body doesn’t eject the placenta and the fetus. This might even mean turning down the immune system in some ways, or for some periods of time. Turning down the immune system too much, though, risks leaving women sensitive to pathogens, which would also be bad for the fetus. So instead the mother’s immune system ramps up in other ways throughout adulthood, Wilson and her colleagues think, so as to remain vigilant against germs even when some of its parts become dormant during pregnancies.

Things get complicated, however, when those pregnancies don’t actually occur. Women today tend to have far fewer children—fewer than two on average in the United States, according to the CDC. Wilson reasons that without a more or less constant pushback from placentas during pregnancies—the pushback that women’s immune systems have evolved to anticipate—the immune system can get too aggressive, too ramped up. It starts looking for things to attack that aren’t dangerous, which is how autoimmune diseases set in.

For millions of years, minus the past 100, “the immune system was expecting to have exposure to a placenta,” Wilson says. Imagine if you’re pulling on something heavy, and then the rope snaps. “If you suddenly don’t have that heavy thing anymore,” she says, “you’re gonna go off the moon.”

This is certainly not the first theory for why women suffer from more autoimmune disease than men do. One has to do with a protein called BAFF; another has to do with the fact that women have two X chromosomes instead of one. The way Wilson sees it, the pregnancy-compensation hypothesis synthesizes many of the previous theories into one and provides the evolutionary explanation behind them. “They were all right,” she says. “But everyone was looking under their own streetlight, and we just waited for it to be daytime.”

Wilson says that so far, no one has come forward to attack her for being wrong, despite the seeming boldness of this theory. Several experts I spoke with—even those who have competing theories for the sex difference in autoimmune disease—say Wilson’s theory might fit with what we already know. “I would say there’s not one theory that explains all [autoimmune diseases],” says Nikolaos Patsopoulos, an assistant professor of neurology at Brigham and Women’s Hospital. “This isn’t Lord of the Rings.” Still, he says, “this theory puts together a lot of things we know that are true and some that we’re still trying to understand.”

Johann E. Gudjonsson, a professor of skin molecular immunology at the University of Michigan, found that women have more of a molecular switch called VGLL3 in their skin than men do, and that all this VGLL3 might be what causes a heightened immune response in women. In this case, then, the VGLL3 might be how the body ramps up the immune system, but the pregnancy-compensation hypothesis might be why it does so.

Similarly, Hal Scofield, a professor of pathology and medicine at the University of Oklahoma, says that it appears there are lots of genes involved in the immune response on the X chromosome, and because women have two X chromosomes while men have only one, women have more of those immune genes. The placental theory that Wilson’s team devised could be the reason this happens. Because women have to have strong immune systems that buck against the placenta, they evolved to produce more genes involved in the immune response. “I don’t think there’s any way out of thinking that placental pregnancy has to have influenced the evolutionary immune system,” Scofield told me.

Not everyone I reached was impressed by the paper. David Hafler, a professor of neurology at the Yale School of Medicine, told me, “Ideas are cheap. It’s data which is hard to get.” In other words, sure, the pregnancy-compensation hypothesis is an interesting idea, but it still has to be tested.

Wilson says there are opportunities to do just that. Scientists could try to determine whether the number of pregnancies a woman has is predictive of her risk of autoimmune disease. If Wilson’s theory holds, women who have more pregnancies should have a lower risk. Or scientists could study the differences between mammals in the wild and zoo animals, which are sometimes on birth control, to determine whether they have differences in their autoimmune function.

Some people might take Wilson’s findings to mean that women should simply be pregnant all the time, but that’s far from the takeaway here. Pregnancy, after all, also carries major health risks, and not all women want to have 12 kids. And Wilson’s findings suggest that women’s extra-strong immune systems might protect them in some cases. Women are less likely than men to get certain kinds of nonreproductive cancers, for example.

Wilson says that the hope is to eventually learn what it is in the immune system that’s trying to respond to the placenta, and to target that thing with vaccines or treatments. More research could mean major improvements in the way women’s autoimmune diseases are treated. “I’ve never been more excited about an idea than I am about this,” Wilson told me. “This is the first time that I can see my work having a direct impact in the next 10 years on human health.”

Source: http://bit.ly/2JlFV53

Iranian lawyer who defended women’s right to remove hijab gets 38 years, 148 lashes.

Join us: facebook.com/unitedhumanists

Iranian lawyer who defended women’s right to remove hijab gets 38 years, 148 lashes.

Nasrin Sotoudeh, an internationally renowned human rights lawyer jailed in Iran, has been handed a new sentence that her husband said was 38 years in prison and 148 lashes.

Sotoudeh, who has represented opposition activists including women prosecuted for removing their mandatory headscarf, was arrested in June and charged with spying, spreading propaganda and insulting Iran’s supreme leader, her lawyer said.

She was jailed in 2010 for spreading propaganda and conspiring to harm state security – charges she denied – and was released after serving half of her six-year term. The European parliament awarded her the Sakharov human rights prize.

Sotoudeh’s husband, Reza Khandan, wrote on Facebook that the sentence was decades in jail and 148 lashes, unusually harsh even for Iran, which cracks down hard on dissent and regularly imposes death sentences for some crimes.

Iran, often accused of human rights abuses, said it had allowed the UN deputy high commissioner for human rights, Kate Gilmore, to visit last week at the head of a “technical mission”.

The visit, confirmed by a UN official, appeared to be the first in many years by UN human rights investigators, who have been denied access by the government.

The UN investigator on human rights in Iran, Javaid Rehman, raised Sotoudeh’s case at the UN human rights council in Geneva on Monday, saying that last week that she “was reportedly convicted of charges relating to her work and could face a lengthy prison sentence”.

He added: “Worrying patterns of intimidation, arrest, prosecution and ill-treatment of human rights defenders, lawyers and labour rights activists signal an increasingly severe state response.”

Source:  http://bit.ly/2RRifIx